Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus

12 de março de 2021

Yunnan Baiyao reduz a incidência de ulceras de pressão adquiridas em hospitais através da supressão da do gene de virulência e da formação de biofilme do Staphylococcus aureos 

Autores

Jun Liu, Mufa Cai, Huimin Yan, Jiawu Fu, Guocai Wu, Zuguo Zhao, Yi Zhao, Yan Wang, Yuanming Sun, Yongke You, Liyao Lin, Juan Huang, Riming Huang, Jincheng Zeng

Abstract

Yunnan Baiyao (YB) as a kind of famous Chinese herbal medicine, possessed hemostatic, invigorating
the circulation of blood, and anti-inflammatory effects. Identifying strategies to protect patients at
risk for hospital-acquired pressure ulcers (HAPU) is essential. Herein, our results showed that YB
treatment can effectively reduce the acne wound area and improve efficacy in a comparative study of
60 cases HAPU patients with S. aureus positive of acne wound pathogens. Furthermore, YB inhibited
HIa expression and suppressed accessory gene regulator (agr) system controlled by regulatory RNA
II and RNA III molecule using pALC1740, pALC1742 and pALC1743 S. aureus strain linked to gfpuvr
reporter gene. Moreover, YB downregulated cao mRNA expression and inhibited coagulase activity
by RT-PCR, slide and tube coagulase test. Additionally, YB downregulated seb, sec, sed, and tsst-1
mRNA expression to suppress enterotoxin and tsst-1 secretion and adhesion function related genes
sarA, icaA, and cidA mRNA expression. Taken together, the data suggest that YB may reduce HAPU
via suppressing virulence gene expression and biofilm formation of S. aureus.

Key words

Yannan Baiyao, hospital-acquired pressure ulcers, Staphylococcus aureus, agr system, virulence factors,
biofilms.

Palavras chaves

Hervas chinesas, ulceras de decúbito, Estafilococus aureus, sistema agr, fatores de virulencia, biofilme

Comentar este artigo

Você precisa estar logado para comentar os artigos.
Desenvolvido por logo-crowd