Use of maropitant for the control of pruritus in non-flea, non-food induced feline hypersensitivity dermatitis: an open-label, uncontrolled pilot study

18 de março de 2021

Uso de maropitant para o controle de prurido em hipersensibilidade felina não induzida por pulgas e não alimentos dermatite: um rótulo aberto, estudo piloto não controlado

Autores

Elisa Maina and Jacques Fontaine

Abstract

Objectives Non-flea, non-food-induced hypersensitivity dermatitis (NFNFIHD) is a common inflammatory and pruritic skin disease in cats. When avoidance and conventional systemic immunosuppressive treatments fail to control the clinical signs, there are limited treatment options. The aim of this study was to evaluate the efficacy and
tolerability of maropitant in feline NFNFIHD.
Methods In an open-label, uncontrolled study, cats with proven non-seasonal NFNFIHD were treated with
maropitant 2 mg/kg PO q24h for 4 weeks. Clinical lesions were evaluated with the Scoring Feline Allergic Dermatitis
(SCORFAD) system and pruritus was evaluated with a 10 cm visual analogue scale (VAS) before and at the end
of the study. Owners assessed global efficacy and tolerability with a 4-point scale at the end of the study. Adverse
events and body weight changes were recorded.
Results Twelve cats were treated with a mean initial maropitant dose of 2.22 mg/kg PO q24h. The treatment
decreased both SCORFAD and pruritus VAS (pVAS) scores in all cats except one, in which only pruritus was
reduced. The efficacy and the tolerability of the treatment were judged as excellent or good by 83.3% of owners.
Treatment did not cause any side effects other than, in a few cases, short-time, self-limiting sialorrhoea.
Conclusions and relevance Maropitant seems to be an effective, well-tolerated therapeutic option to control pruritus
in cats. Caution is needed in interpreting the results as the pVAS score system has not yet been validated in cats
and the trial was uncontrolled. A further, controlled study is required to confirm our findings.

Keywords: maropitant, hypersensitivity, NK-1 receptor antagonist, atopic dermatitis, treatment

Palavras chave: maropitam, hipersensibilidade, receptor NK-1 agonista, dermatite atópica, tratamentp

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