Top 5 Lip Depigmentation Causes in Dogs

5 de dezembro de 2020

Top 5 Despigmentação de lábios - Causas em cães

Alexander Werner

Skin pigmentation in mammals is primarily produced by the transfer of eumelanin (ie, black–brown
pigment) and pheomelanin (ie, yellow–red pigment)
within melanosomes through the dendritic processes of melanocytes to adjacent keratinocytes in
the basal cell layer.1
In dogs, the dendritic processes
of one melanocyte are associated with 10 to 20 keratinocytes to produce the epidermal melanin unit.2
Because of the cytotoxicity of synthesis intermediates, melanogenesis is confined within melanocytes to the membrane-bound melanosomes.2
Abnormal loss or absence of pigmentation (ie, leukoderma or hypomelanosis, respectively) can be
caused by reduced pigment production and/or loss
of melanocytes.
The lip margin in dogs is highly visible and often
darkly pigmented. Both the degree and pattern of
normal pigmentation differ by breed type and individual dog. Thus, determining whether pigmentation changes suggest a pathologic process must be
based on what is normal or abnormal for each dog
and on the presence or absence of inflammation
and/or pigmentation changes at other locations. In
general, acute inflammation often produces depigmentation, whereas chronic inflammation may lead
to hyperpigmentation.
Following are the author’s top 5 causes of lip
depigmentation in dogs.

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