Outcome of non-surgical dietary treatment with or without lactulose in dogs with congenital portosystemic shunts

28 de setembro de 2020

Resultado do tratamento dietético não cirúrgico com ou sem lactulose em cães com desvios portossistêmicos congênitos

Autores

Robert P Favier, Eline de Graaf, Ronald J Corbee, Anne Kummeling

Abstract

Background

Congenital portosystemic shunts (CPSS) are vascular anomalies, allowing portal blood to bypass the hepatic parenchyma, thereby accumulating toxic substances such as ammonia in the systemic circulation resulting in hepatic encephalopathy.

Aim

To evaluate the outcome of non-surgically treated dogs with a CPSS.

Methods

Case records of 78 dogs with a single congenital CPSS confirmed by ultrasound and/or computed tomography between September 2003 and February 2015 were reviewed. Median age at diagnosis of CPSS in dogs was 10.8 months (range 2-133 months). Non-surgical treatment was started as an adjusted diet (a diet restricted in protein) with or without lactulose. Owners were contacted by telephone to determine survival time and presumed cause of death, if applicable. In addition, a questionnaire was used to retrospectively assess quality of life (QoL) and CPSS scores in 37 dogs before and during non-surgical treatment. Differences between Kaplan-Meier curves were tested by a Log rank test.

Results

Overall estimated median survival time (EMST) was 38.5 months (range 1 day - 91 months; 78 dogs). No significant differences between EMSTs were found between dogs with extra- (n = 48) or intrahepatic (n = 29) shunts, nor between treatment with only an adjusted diet, or an adjusted diet combined with lactulose. During non-surgical treatment, significant improvement in perceived QoL and CPSS scores were found (P < 0.01).

Conclusion

Our study demonstrated that an overall median EMST of 3.2 years was reached and that owners retrospectively perceived that non-surgical treatment resulted in an improved QoL and clinical performance, irrespective of intrahepatic or extrahepatic CPSS location.

Keywords

canine; congenital portosystemic shunt; non-surgical treatment; quality of life; survival

Palavras chave

canino; shunt portossistêmico congênito; tratamento não cirúrgico; qualidade de vida; sobrevivência

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