Oral Mutian®X stopped faecal feline coronavirus shedding by naturally infected cats

30 de abril de 2020

Diane D. Addiea,⁎,1
, Sheryl Curranb
, Flora Bellinic
, Ben Crowec
, Emily Sheehand
,
Lesya Ukrainchuke
, Nicola Decarof

Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a
potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian®
Xraphconn (Mutian X) is a product marketed to treat cats with FIP but is also being used to stop virus shedding,
although no clear guidelines exist for its use for this purpose. The aim of this study was to establish the minimum
dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding
cats. In five multicat households, 29 cats naturally infected with FCoV and actively shedding virus in the faeces
were given Mutian X pills. Virus shedding was monitored using reverse-transcription quantitative polymerase
chain reaction (RT-qPCR) controlled for faecal inhibitors to ensure sensitivity. Mutian X given orally cleared the
virus in 29 cats; although four cats required a repeated course to finally stop virus shedding. A dose of 4 mg/kg
q24 h for four days was found to be the optimal treatment protocol: 2 mg/kg cleared only 80% of cats. Posttreatment using a sensitive RT-qPCR test was essential to ensure that virus clearance had been achieved, since
failure to clear even one cat can result in re-infection of the others. Records of virus shedding by cats before
treatment provided a retrospective control: significantly more cats stopped shedding virus after Mutian X than
recovered from infection during the control period (p < .00001). This is the first report of the successful
elimination of faecal FCoV shedding in chronically infected cats.

Peritonite infecciosa felina, PIF, FIP, Mutian Adenosine, e GS-441524 (GS), adenosina, RNA virus, Coronavirus
G376 (GC)

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