Efficacy of medium chain triglyceride oil dietary supplementation in reducing seizure frequency in dogs with idiopathic epilepsy without cluster seizures: a non-blinded, prospective clinical trial

9 de fevereiro de 2021

Eficácia da suplementação com óleo triglicerídeo de cadeia média em reduzir a frequência de convulsões em cães com epilepsia idiopática sem crises agrupadas: um  ensaio clínico prospectivo não, cego.

Autores

Jenifer MolinaClementine Jean-PhilippeLisa Conboy,  Sonia AñorCristian de la FuenteMarcin Adam WrzosekAndrea SpycherEva LuchsingerBettina Wenger-RiggenbachPatricia MontoliuGualtiero GandiniMarika MenchettiJoão Carlos RibeiroArtur VarejãoAntonio FerreiraBrian ZanghiHolger Andreas Volk

Abstract

Background: Despite appropriate antiseizure drug (ASD) treatment, around two-thirds of dogs with idiopathic epilepsy (IE) have seizures long-term and 20-30 per cent of affected dogs remain poorly  ontrolled.

Methods: The current study aim is to test in a field trial the efficacy and tolerability of a commercially available diet enriched with 6.5 per cent medium chain triglyceride (MCT) oil in dogs (n=21) with at least a tier 1 idiopathic epilepsy diagnosis, without cluster seizures, in 10 veterinary practices across Europe. Each dog's quality of life (QoL), ataxia, sedation and frequency and severity of seizures were recorded by owners throughout the study.

Results: The mean seizure frequency per month, averaged over the entire 84-day study, significantly (P=0.04) decreased 32 per cent compared with the baseline monthly seizure frequency recorded during the month immediately before feeding the diet. Similarly, the seizure days rate (days/month) also declined (P<0.001) by 42 per cent. QoL was reported as very good to excellent (>8.5/10) in 20 of the 21 dogs before starting the diet and this remained unchanged during the trial.

Conclusions: This study demonstrates the use of a diet enriched with MCTs as an adjunct to ASD treatment may have some antiseizure properties for dogs diagnosed with IE, as demonstrated in previous studies.

Keywords

canine; diet; epilepsy; medium chain triglycerides; seizures.

Palavras-chave

canino; dieta; epilepsia; triglicerídeos de cadeia média; convulsões.

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