Effects of pimobendan on left atrial transport function in cats

2 de dezembro de 2020

Efeito do Pimobendan na função atrial esquerda em gatos.

Samantha L. Kochie, Karsten E. Schober, Jaylyn Rhinehart, Randolph L. Winter, John D. Bonagura, Annie Showers, Vedat Yildez

Abstract

Background: Arterial thromboembolism is a sequela of hypertrophic cardiomyopathy (HCM) in cats related to left atrial (LA) enlargement and dysfunction.
Hypothesis: Pimobendan improves LA transport function in cats.
Animals: Twenty-two client-owned cats with HCM and 11 healthy cats.
Methods: Prospective, double-blind, randomized, placebo-controlled clinical cohort
study. Cats were randomized to receive either pimobendan (0.25 mg/kg PO q12h) or placebo for 4 to 7 days. Nineteen echocardiographic variables of LA size and function were evaluated. Statistical comparisons included t tests, analysis of variance, and multivariable analyses.
Results: Peak velocity of left auricular appendage flow (LAapp peak; mean ± SD, 0.85 ± 0.20 vs 0.71 ± 0.22 m/s; P = .01), maximum LA volume (P = .03), LA total emptying volume (P = .03), peak velocity of late diastolic transmitral flow (A peak velocity; 0.77 ± 0.12 vs 0.62 ± 0.17 m/s; P = .05), and A velocity time integral (A VTI; 3.05 ± 0.69 vs 3.37 ± 0.49; P = .05) were increased after pimobendan. Mean change after pimobendan was larger in cats with HCM compared to healthy cats for LA fractional
shortening (2.1% vs −2.1%; P = .05), A VTI (0.58 vs 0.01 cm; P = .01), LAapp peak (0.20 vs 0.02 m/s; P = .02), LA kinetic energy (3.51 vs −0.10 kdynes-cm; P = .05), and LA ejection force (1.93 vs −0.07 kdynes; P = .01) in the multivariable model. The stronger effect of pimobendan in cats with HCM was independent of LA size.
Conclusions and Clinical Importance: We identified positive, albeit minor, effects of pimobendan on LA function in cats with HCM. Whether or not treatment with pimobendan decreases the risk of cardiogenic embolism deserves further study

Keywords

Arterial thromboembolism, echocardiography, feline, hypertrophic cardiomyopathy, Vetmedin

Palavras chaves

Tromboembolismo arterial, ecocardiografia, cardiomiopatia hipertrófica, Vetmedin

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