Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

7 de fevereiro de 2021

Infusão contínua de midazolam como tratamento emergente para convulsões em cães

Autores

Kathryn Y. Bray, Christopher L. Mariani, Peter J. Early, Karen R. Muñana, Natasha J. Olby

Abstract

Background: Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE).
Objective: To describe the use and safety of midazolam CRI in dogs with CS or SE.
Animals: One-hundred six client-owned dogs presenting to a veterinary teaching hospital with CS or SE.
Methods: Retrospective review of medical records for dogs with CS or SE treated with a midazolam CRI.
Results: Seventy-nine dogs presented with CS and 27 dogs had SE. Seizure control was achieved in 82/106 dogs (77.4%) receiving a midazolam CRI. The median dose associated with seizure control was 0.3 mg/kg/h (range, 0.1-2.5 mg/kg/h). The median duration of CRI was 25 hours (range, 2-96 hours). Seizures were controlled in 34/40 dogs (85%) with idiopathic epilepsy, 32/43 dogs (74%) with structural epilepsy, 12/16 dogs (75%) with unknown epilepsy, and 4/7 dogs (57%) with reactive seizures (P = .20). Seizure control was achieved in 81% of dogs with CS and 67% in dogs with SE (P = .18). Dogs with idiopathic/unknown epilepsy were more likely to survive than those with structural epilepsy (87% vs 63%, P = .009). Adverse effects were reported in 24 dogs (22.6%) and were mild in all cases.
Conclusions and Clinical Importance: Midazolam CRI is apparently safe and might be an effective treatment in dogs with CS or SE.

Keywords

acute repetitive seizures, anticonvulsant, benzodiazepine, canine, cluster seizures, epilepsy, status epilepticus

Palavras-chave

convulsões repetitivas agudas, anticonvulsivante, benzodiazepínico, canino, convulsões em salvas, epilepsia, estado de mal epiléptico

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