Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study

8 de dezembro de 2020

Riscos associados à raça para o desenvolvimento linfoma canino difere entre os países: uma rede europeia de estudo do linfoma canino

Autores
Stefano Comazzi1, Stefano Marelli, Marzia Cozzi, Rita Rizzi, Riccardo Finotello, Joaquim Henriques, Josep Pastor, Frederique Ponce, Carla Rohrer-Bley, Barbara C. Rütgen and Erik Teske

Abstract

Background: Canine breeds may be considered good animal models for the study of genetic predisposition to
cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some
breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and
geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with
the aim of investigating the breed prevalence of canine lymphoma in different European countries and of
investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes.
Results: A total of 1529 canine nodal lymphoma cases and 55,529 control cases from 8 European countries/institutions
were retrospectively collected. Odds ratios for lymphoma varied among different countries but Doberman, Rottweiler,
boxer and Bernese mountain dogs showed a significant predisposition to lymphoma. In particular, boxers tended to
develop T-cell lymphomas (either high- or low-grade) while Rottweilers had a high prevalence of B-cell lymphomas.
Labradors were not predisposed to lymphoma overall but tended to develop mainly high-grade T-cell lymphomas. In
contrast with previous studies outside of Europe, the European golden retriever population did not show any possible
predisposition to lymphoma overall or to specific subtypes such as T-zone lymphoma.
Conclusion: Further prospective studies with more precise and consistent subtype identification are needed to
confirm our retrospective results and to create the basis for the investigation of possible genes involved in different
predispositions.

Keywords: Dog, Lymphoma, Breed risk, Predisposition, Odds ratio

Comentar este artigo

Você precisa estar logado para comentar os artigos.
Desenvolvido por logo-crowd