A multicenter randomized controlled trial of medium-chain triglyceride dietary supplementation on epilepsy in dogs
Um ensaio multicêntrico randomizado controlado de cadeia média suplementação dietética de triglicerídeos na epilepsia em cães
Benjamin A. Berk, Tsz H. Law, Rowena M. A. Packer, Annette Wessmann, Andrea Bathen-Nöthen, Tarja S. Jokinen, Anna Knebel, Andrea Tipold, Ludovic Pelligand, Zoe Meads and Holger A. Volk
Background: Medium-chain triglyceride (MCT) enriched diet has a positive effect on seizure control and behavior in some dogs with idiopathic epilepsy (IE).
Objective: To evaluate the short-term efficacy of MCTs administered as an add-on dietary supplement (DS) to a variable base diet to assess seizure control and anti-seizure drug's (ASD) adverse effect profiles.
Animals: Twenty-eight dogs with International Veterinary Epilepsy Task Force Tier II (IVETF) level diagnosis of treated IE with 3 or more seizures in the last 3 months were used.
Methods: A 6-month multicenter, prospective, randomized, double-blinded, placebo controlled crossover trial was completed, comparing an MCT-DS with a control-DS.
A 9% metabolic energy-based amount of MCT or control oil was supplemented to the dogs' diet for 3 months, followed by a control oil or MCT for another 3 months, respectively. Dogs enrolled in this study satisfied most requirements of IE diagnosis stated by the IVETF II level. If they received an oil DS or drugs that could influence
the metabolism of the investigated DS or chronic ASD, the chronic ASD medication was adjusted, or other causes of epilepsy were found, the dogs were excluded from the study.
Keywords: medium-chain triglyceride, idiopathic epilepsy, seizure, anti-seizure drug
Palavras-chave: triglicerídeo de cadeia média, epilepsia idiopática, convulsão, medicamento anticonvulsivante